Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material.

Effect of sterilisation by gamma irrradiation on the ability of polycaprolactone ( PCL ) to act as a scaffold material

Nanofibrillated chitosan/polycaprolactone bionanocomposite scaffold with improved tensile strength and cellular behavior

Objective(s): Fabrication of scaffolds with improved mechanical properties and favorable cellular compatibility is crucial for many tissue engineering applications. This study was aimed to improve mechanical and biological properties of polycaprolactone (PCL), which is a common biocompatible and biodegradable synthetic polymer in tissue engineering. Nanofibrillated chitosan (NC) was used as a n...

Enhanced Adipose Mesenchymal Stem Cells Proliferation by Carboxymethyl-Chitosan Functionalized Polycaprolactone Nanofiber

Background: Through combining two synthetic and natural polymers, scaffolds can be developed for tissue engineering and regenerative medicine purposes. Methods: In this work, carboxymethyl chitosan (CMC; 20%) was grafted to Polycaprolactone (PCL) nanofibers using the cold atmospheric plasma of helium. The PCL scaffolds were exposed to CAP, and functional groups were developed on the PCL surface...

Effect of Nanoclay Addition on the Properties of Polycaprolactone Nanocomposite Scaffolds Containing Adipose Derived Mesenchymal Stem Cells used in Soft Tissue Engineering

Tissue-engineering scaffolds provide biological and mechanical frameworks for cell adhesion, growth, and differentiation. Nanofibrous scaffolds mimic the native extracellular matrix (ECM) and play a significant role in formation and remodeling of tissues and/or organs . One way to mimic the desired properties of fibrous ECM is adding nanoparticles into the polymer matrix. In the current study, ...

Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold

Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospu...